Let’s take a look at the location for most of the game-play in Star Trek: Borderlands.
Our game takes place in the 25 century in the Delta Quadrant of the galaxy.
Federation colonization of the Delta Quadrant has left Starfleet overtaxed and overextended. The newly-formed Delta Freedom Alliance vies with the Federation for the hearts and minds of the Delta Quadrant denizens, and numerous criminal and terrorist factions have set up shop in this wild and lawless region of space. There are also colonies and ships of the Romulan Star Empire in the Delta Quadrant. Additionally, a split in the Klingon High Council has deposited a vanguard fleet here, intent on proving the viability of a Klingon Territory.
As you can see, we are right at the outer edge of the territories dealt with in the series Star Trek: Voyager. This is previously unknown space made accessible by the Genosh Wormhole.
Our crews face the unknown on a regular basis, but they must also deal with the same old Alpha Quadrant politics as they eke out their existence and explore this vast new Frontier. That is why we call it 'Borderlands'.